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Effects of Continuous Positive Airway Pressure on Cardiac
Volumes in Patients with Ischemic and Dilated Cardiomyopathy
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Long-term nightly application
of nasal continuous positive airway pressure (CPAP) to patients
with congestive heart failure (CHF) and central sleep
apnea leads to improvements in cardiovascular
mechanical and neurohumoral function
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Photo by Eddie Sperling |
11/13/2004
The effects of
continuous positive airway pressure (CPAP) on
left (LV) and right ventricular (RV) volumes in patients with
congestive heart failure (CHF) have not been studied. We
hypothesized that CPAP would cause greater reductions in
cardiac volumes in CHF patients with idiopathic dilated
cardiomyopathy (IDC) than in those with ischemic
cardiomyopathy (IsC), because their ventricles are more
compliant. The effects of a 30-min CPAP application at
10 cm H2O on RV and LV end-diastolic (EDV) and
end-systolic volumes (ESV), determined by radionuclide
angiography, were therefore tested in 22 patients with
CHF due to IsC (n = 13) or IDC (n = 9). CPAP-induced
reductions in LVEDV, LVESV, RVEDV, and RVESV were
significantly greater (p < 0.05) in the IDC than in the IsC
group. Whereas in the IsC group
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